Weight Cycling Physiology Articles
Detailed explorations of metabolic adaptation and repeated weight cycling
Detailed explorations of metabolic adaptation and repeated weight cycling
Our comprehensive articles examine the physiological mechanisms, research findings, and metabolic consequences of repeated weight cycling. Each article provides detailed explanations grounded in scientific literature.
Explore the mechanisms of metabolic rate reduction during caloric restriction, including sympathetic nervous system changes, thyroid hormone dynamics, and the evolutionary basis of adaptive thermogenesis.
Read Article →Understand how NEAT suppression occurs during dieting phases, the role of dopaminergic pathways in reduced spontaneous physical activity, and the persistence of NEAT suppression into refeeding.
Read Article →Learn why refeeding phases result in preferential fat mass recovery, the hormonal factors driving this outcome, and the implications for body composition and metabolic health across cycles.
Read Article →Discover research findings on how repeated cycles affect mitochondrial function, oxidative capacity, substrate utilisation, and the potential long-term consequences for cellular energy metabolism.
Read Article →Examine changes in appetite regulation hormones, including leptin resistance patterns, hypothalamic adaptations, and the persistence of hunger signalling disturbances across multiple cycles.
Read Article →Review the genetic, physiological, and environmental factors influencing individual differences in weight-cycling responses, and why population-level findings may not apply universally.
Read Article →All Cyclara articles are grounded in peer-reviewed scientific literature, including metabolic ward studies, animal weight-cycling models, long-term human cohort data, and meta-analyses. We provide evidence-based information presented with scientific nuance and acknowledgment of research limitations.
Each article explains complex physiological mechanisms in accessible language whilst maintaining scientific accuracy. We acknowledge areas of ongoing investigation and avoid overgeneralising from limited or conflicting evidence.
Explore our home page for summaries of key physiological mechanisms and frequently asked questions about weight cycling physiology.
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